AutoImmune Disorder

Miss A. presented to her doctor's clinic for complaints of extreme dry eye syndrome, butterfly rashes on face, cheeks, mouth ulcer, and joint pain. The doctor ordered ANA, ESR, RF(Rheumatoid Factor),SS-A, SS-B and Sedimentation rate. All her lab results are normal except ANA=165. Her doctor referred her to a specialist for what potential condition?

A. Rheumatoid Arthritis
B. Polyserositis.
C. Sjogren's syndrome
D. Systemic Lupus Erythematosus

What is elevated in Rheumatoid Arthritis? ESR, Sed rate, RF
What is elevated in Sjogren's syndrome? RF, SS-A and SS-B antibodies, and possibly ANA
What is elevated in SLE? ANA

Why not A? Her ESR,Sedimentation rate, RF are normal
Why not B? Polyserositis is also a symptom of SLE. Taken together, is an inflammation of heart lining (pericarditis), inflammation of lining of the lung (pleurisy), and/ or inflammation around the abdomen(peritonitis)
Why not C? The RF, SS-A and SS-B, called the Sjogrens antibodies are normal

Answer: Systemic Lupus Erythematosus (SLE) Why? ANA is positive, normal= 1-160.And have symptoms of joint pain, mouth ulcer, butterfly rash on cheeks.

Most common symptoms of SLE:
1. Fever (maximum temperature usually less than 102°F)
2. Joint pain or swelling (most commonly in the hands, wrists, and knees)
3. Muscle pain
4. Hair loss
5. Rash (typically in a "butterfly" distribution on the face, across the cheeks, and under the eyes)
6. Painless ulcers in the mouth or nose
7. Photosensitivity (the development of a rash on sun-exposed skin)